Introduction cell death is part of normal development and maturation cycle, and is the component of many response patterns of. Biochemical events lead to characteristic cell changes and death. Apr 27, 2016 bibliografia patologia estructural y funcional octava edicion robbins y cotran. In this case, it is an orderly process and part of normal immune system maturation. Apoptosis and necrosis were initially considered as mutually exclusive states. Differential induction of apoptosis and necrosis in. Several common mediators of both cell death types have been identified. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal dna fragmentation, and global vague mrna decay.
Muerte celular, apoptosis y necrosis by eduard guerrero on. Biochemical events lead to characteristic cell changes morphology and death. Cell death in viral infections that induce apoptosis such as hiv and adenovirus or by the host immune response such as hepatitis. Autophagy can serve either prosurvival or prodeath functions. Because apoptosis cannot stop once it has begun, it is a highly regulated process. Apoptosis is an integral part of normal tissue development and homeostasis, eliminating redundant cells during embryogenesis. Genes such as bcl2 are turned off and bax genes turned on. Definition of apoptosis and overview of it incidence. Normalmente, cuando algo va mal en una celula, esta es rapidamente destruida por apoptosis. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
Muerte celular programada, suicidio celular, necrobiosis, muerte con encogimiento. The cell cycle is a complex process of reproduction that has the ultimate goal of obtaining two identical daughter cells. During this process, the cell determines checkpoints and restrictions to. In the recent literature, cell death is said to occur by two alternative, opposite modes. Apoptosis in pathologic conditions dna damage due to radiation, chemotherapy. Crosstalk between apoptosis, necrosis and autophagy. Apoptosis and cell necrosis free download as powerpoint presentation. Although initially thought to constitute mutually exclusive cellular states, recent findings reveal cellular contexts that require a balanced interplay between these two.
Necrosis severe damage metabolism stop structure destroy function lose. Apoptosis y necrosis muerte celular programada necrosis apoptosis 6. Apoptosis y efecto cardiovascular 74 clin invest arterioscl 2003. Localized death of cell or tissue occurring in the living body. Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of which have been extensively studied. Individual cells fragment and are consumed by phagocytes to give the appearance of clear spaces filled with cellular debris. Simultaneous detection of apoptosis and necrosis was performed by double staining with 3,3. Introduction apoptosis is the process of programmed cell death. Recent findings reveal a balanced interplay between apoptosis and necrosis. Apoptosis and necrosis are the two major modes of cell. Accumulation of misfolded proteins leads to er stress which ends with apoptosis.