Abstract granulomatous lung diseases are a heterogeneous group of disorders that have a wide. Both infectious and noninfectious diseases can be associated with granuloma formation. The disease is known to affect people of all age groups and while around 40% patients respond well to treatment. The term granulomatous lung disease does not refer to a specific disease entity, but to a wide spectrum of pathologies with variable clinical manifestations and outcomes. There may be hepatosplenotable 3 granulomatous mycobacterial infections clinical disorder common site mycobacteria tuberculosis lung m tuberculosis meninges skin intestine leprosy skin m leprae. Precise clinical evaluation, laboratory testing, pulmonary function testing, radiological imaging including highresolution computed tomography and often histopathological assessment contribute to make a confident diagnosis of granulomatous lung diseases.
Diffuse parenchymal lung disease dpld represents a large and. Due to congenital enzymatic defect of nadph oxidase in granulocytes and monocytes white blood cells cannot generate superoxide ion which kills microorganisms in lysosomes. A working diagnosis of common variable immunodeficiency cvid was made, with differential diagnoses of sarcoidosis, atypical pulmonary infection and. Gal, md from the department of pathology, state university of new york upstate medical university, syracuse, new york dr mukhopadhyay. Chronic granulomatous disease cgd is an inherited genetic immune system disorder that occurs when a type of white blood cell phagocyte that usually helps your body fight infections doesnt work properly. Granulomatous lung disease an approach to the differential. The most common example is the chronic foreign body granuloma, but most granulomatous diseases involve granulomas which comprise mostly epithelioid macrophages, with variable numbers of macrophage giant cells.
Chronic granulomatous disease cgd is a rare, inherited immunodeficiency that affects certain white blood cells. Pathological diagnosis of granulomatous lung disease. Chronic granulomatous disease genetic and rare diseases. Pathological diagnosis of granulomatous lung diseases dr. Differential diagnosis of granulomatous lung disease. Granuloma, lymphoid interstitial lung disease, common. Request pdf granulomatous lung disease an approach to the differential diagnosis granulomas are among the most commonly encountered abnormalities. Granulomatous lung disease can be localized and nonorgan threatening, or lifethreatening. Pdf expression profiling in granulomatous lung disease.
Abstract granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. The patients are predisposed to bacterial and fungal infections. Granulomatous disease synonyms, granulomatous disease pronunciation, granulomatous disease translation, english dictionary definition of granulomatous. Diffuse interstitial lung disease frequently results in morbidity and mortality due to lung injury and fibrosis. As a result, the phagocytes cant protect your body from bacterial and fungal infections. Jcm free fulltext interstitial lung disease and pulmonary. Granulomatous and lymphocytic interstitial lung disease glild.
Pdf the frequencies of various causes of pulmonary granulomas in pathological material are unknown, as is the influence of. Noninfectious causes of lung granulomas include conditions such as sarcoidosis and wegeners granulomatosis. Chronic granulomatous disease symptoms and causes mayo. Research reveals that the incidence of the onslaught is at 10 to a million, every year. Pathological diagnosis of granulomatous lung diseases. Differential diagnosis of granulomatous lung disease european. The term granulomatous lung disease does not refer to a specific disease entity, but to. Chronic granulomatous disease is a rare disorder in which the phagocytes fail to produce hydrogen peroxide. People with this condition have immune systems that do not function properly, leaving the body vulnerable to chronic inflammation and frequent bacterial and fungal infections. Diffuse parenchymal lung disease karger publishers. Granulomatous lung diseases, such as sarcoidosis, hypersensitivity pneumonitis, wegeners granulomatosis, and chronic beryllium disease, along with. Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum. Expression profiling in granulomatous lung disease ncbi nih.